Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq epigenetics
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

orcid logoAnika Erxleben avatar Anika ErxlebenVivek Bhardwaj avatar Vivek Bhardwajorcid logoMallory Freeberg avatar Mallory Freebergorcid logoKatarzyna Kamieniecka avatar Katarzyna Kamienieckaorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoFlorian Heyl avatar Florian Heylorcid logoMartin Čech avatar Martin Čechorcid logoHans-Rudolf Hotz avatar Hans-Rudolf HotzEkaterina Polkh avatar Ekaterina PolkhVerena Moosmann avatar Verena MoosmannLeily Rabbani avatar Leily Rabbaniorcid logoMo Heydarian avatar Mo Heydarianorcid logoBérénice Batut avatar Bérénice BatutWilliam Durand avatar William DurandDevon Ryan avatar Devon Ryanorcid logoSaskia Hiltemann avatar Saskia HiltemannFriederike Dündar avatar Friederike DündarTorsten Houwaart avatar Torsten HouwaartNiall Beard avatar Niall Beardorcid logoBjörn Grüning avatar Björn GrüningMehmet Tekman avatar Mehmet Tekmanorcid logoAnup Kumar avatar Anup KumarGildas Le Corguillé avatar Gildas Le Corguilléorcid logoLucille Delisle avatar Lucille Delisleorcid logoNicola Soranzo avatar Nicola Soranzoorcid logoCristóbal Gallardo avatar Cristóbal Gallardoorcid logoKhaled Jum'ah avatar Khaled Jum'ahorcid logoMaria Doyle avatar Maria Doyleorcid logoYvan Le Bras avatar Yvan Le Brasorcid logoWolfgang Maier avatar Wolfgang MaierMélanie Pétéra avatar Mélanie Pétéraorcid logoPavankumar Videm avatar Pavankumar VidemJoachim Wolff avatar Joachim Wolfforcid logoArmin Dadras avatar Armin Dadrasorcid logoTristan Reynolds avatar Tristan Reynoldsorcid logoHelena Rasche avatar Helena RascheFidel Ramirez avatar Fidel Ramirez

Funding

These individuals or organisations provided funding support for the development of this resource

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de.NBI
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Australian BioCommons
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UFR
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ELIXIR Europe
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Collaborative Research Centre 992
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Melbourne Bioinformatics
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The University of Melbourne