Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq epigenetics
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

Mehmet Tekman avatar Mehmet TekmanMélanie Pétéra avatar Mélanie Pétéraorcid logoMartin Čech avatar Martin ČechFidel Ramirez avatar Fidel RamirezTorsten Houwaart avatar Torsten Houwaartorcid logoWolfgang Maier avatar Wolfgang Maierorcid logoPavankumar Videm avatar Pavankumar VidemGildas Le Corguillé avatar Gildas Le Corguilléorcid logoKatarzyna Kamieniecka avatar Katarzyna Kamienieckaorcid logoCristóbal Gallardo avatar Cristóbal Gallardoorcid logoMallory Freeberg avatar Mallory FreebergFriederike Dündar avatar Friederike Dündarorcid logoFlorian Heyl avatar Florian Heylorcid logoAnup Kumar avatar Anup Kumarorcid logoTristan Reynolds avatar Tristan ReynoldsVivek Bhardwaj avatar Vivek Bhardwajorcid logoArmin Dadras avatar Armin Dadrasorcid logoAmirhossein Naghsh Nilchi avatar Amirhossein Naghsh Nilchiorcid logoLucille Delisle avatar Lucille Delisleorcid logoNicola Soranzo avatar Nicola SoranzoLeily Rabbani avatar Leily Rabbaniorcid logoHelena Rasche avatar Helena RascheWilliam Durand avatar William DurandDevon Ryan avatar Devon Ryanorcid logoKrzysztof Poterlowicz avatar Krzysztof PoterlowiczVerena Moosmann avatar Verena MoosmannJoachim Wolff avatar Joachim Wolfforcid logoSaskia Hiltemann avatar Saskia HiltemannEkaterina Polkh avatar Ekaterina Polkhorcid logoYvan Le Bras avatar Yvan Le BrasNiall Beard avatar Niall Beardorcid logoHans-Rudolf Hotz avatar Hans-Rudolf Hotzorcid logoAnika Erxleben avatar Anika Erxlebenorcid logoMaria Doyle avatar Maria Doyleorcid logoKhaled Jum'ah avatar Khaled Jum'ahorcid logoBérénice Batut avatar Bérénice Batutorcid logoMo Heydarian avatar Mo Heydarianorcid logoBjörn Grüning avatar Björn Grüning

Funding

These individuals or organisations provided funding support for the development of this resource

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UFR
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Melbourne Bioinformatics
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The University of Melbourne
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ELIXIR Europe
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Collaborative Research Centre 992
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de.NBI
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Australian BioCommons