Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

orcid logoMo Heydarian avatar Mo Heydarianorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoKatarzyna Kamieniecka avatar Katarzyna Kamienieckaorcid logoBérénice Batut avatar Bérénice BatutMehmet Tekman avatar Mehmet TekmanTorsten Houwaart avatar Torsten Houwaartorcid logoMaria Doyle avatar Maria DoyleWilliam Durand avatar William Durandorcid logoCristóbal Gallardo avatar Cristóbal GallardoDevon Ryan avatar Devon RyanLeily Rabbani avatar Leily RabbaniFidel Ramirez avatar Fidel Ramirezorcid logoKhaled Jum'ah avatar Khaled Jum'ahMélanie Petera avatar Mélanie Peteraorcid logoMallory Freeberg avatar Mallory Freebergorcid logoSaskia Hiltemann avatar Saskia HiltemannJoachim Wolff avatar Joachim Wolfforcid logoYvan Le Bras avatar Yvan Le Brasorcid logoAnup Kumar avatar Anup Kumarorcid logoLucille Delisle avatar Lucille DelisleEkaterina Polkh avatar Ekaterina Polkhorcid logoNicola Soranzo avatar Nicola Soranzoorcid logoHans-Rudolf Hotz avatar Hans-Rudolf Hotzorcid logoFlorian Heyl avatar Florian HeylNiall Beard avatar Niall BeardFriederike Dündar avatar Friederike DündarVerena Moosmann avatar Verena Moosmannorcid logoWolfgang Maier avatar Wolfgang Maierorcid logoMartin Čech avatar Martin ČechVivek Bhardwaj avatar Vivek Bhardwajorcid logoTristan Reynolds avatar Tristan Reynoldsorcid logoHelena Rasche avatar Helena Rascheorcid logoArmin Dadras avatar Armin Dadrasorcid logoAnika Erxleben avatar Anika ErxlebenGildas Le Corguillé avatar Gildas Le Corguilléorcid logoPavankumar Videm avatar Pavankumar Videmorcid logoBjörn Grüning avatar Björn Grüning

Funding

These individuals or organisations provided funding support for the development of this resource

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UFR
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Collaborative Research Centre 992
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Melbourne Bioinformatics
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The University of Melbourne
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ELIXIR Europe
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de.NBI
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Australian BioCommons