Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

Torsten Houwaart avatar Torsten Houwaartorcid logoMartin Čech avatar Martin Čechorcid logoHelena Rasche avatar Helena Rascheorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoNicola Soranzo avatar Nicola SoranzoGildas Le Corguillé avatar Gildas Le Corguilléorcid logoAnup Kumar avatar Anup Kumarorcid logoKatarzyna Kamieniecka avatar Katarzyna KamienieckaFidel Ramirez avatar Fidel Ramirezorcid logoLucille Delisle avatar Lucille Delisleorcid logoYvan Le Bras avatar Yvan Le BrasJoachim Wolff avatar Joachim WolffFriederike Dündar avatar Friederike Dündarorcid logoArmin Dadras avatar Armin DadrasVerena Moosmann avatar Verena MoosmannWilliam Durand avatar William Durandorcid logoPavankumar Videm avatar Pavankumar VidemMélanie Petera avatar Mélanie Peteraorcid logoKhaled Jum'ah avatar Khaled Jum'ahorcid logoAnika Erxleben avatar Anika ErxlebenVivek Bhardwaj avatar Vivek Bhardwajorcid logoBjörn Grüning avatar Björn Grüningorcid logoSaskia Hiltemann avatar Saskia Hiltemannorcid logoMo Heydarian avatar Mo Heydarianorcid logoMallory Freeberg avatar Mallory Freebergorcid logoFlorian Heyl avatar Florian Heylorcid logoBérénice Batut avatar Bérénice BatutLeily Rabbani avatar Leily RabbaniEkaterina Polkh avatar Ekaterina PolkhNiall Beard avatar Niall Beardorcid logoMaria Doyle avatar Maria Doyleorcid logoCristóbal Gallardo avatar Cristóbal Gallardoorcid logoWolfgang Maier avatar Wolfgang Maierorcid logoTristan Reynolds avatar Tristan ReynoldsMehmet Tekman avatar Mehmet TekmanDevon Ryan avatar Devon Ryanorcid logoHans-Rudolf Hotz avatar Hans-Rudolf Hotz

Funding

These individuals or organisations provided funding support for the development of this resource

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Melbourne Bioinformatics
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de.NBI
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ELIXIR Europe
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UFR
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The University of Melbourne
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Collaborative Research Centre 992
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Australian BioCommons