What is the advantage of breaking down protein to peptides before mass spec?

Mass spectrometry works better for peptides: LC separation and ionization is working better on peptides than on proteins and proteins generate too complex and overlaying mass spectra due to their isotopes and their mass might be shifted due to posttranslational modifications or point mutations.

Persistent URL

Resource purlPURL: https://gxy.io/GTN:F00285

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