Tuberculosis (TB) is a big killer in many countries of the world, particularly in those with low and middle income. Next-generation sequencing has been key in improving our understanding of drug resistance acquisition and of transmission of Mycobacterium tuberculosis. Yet, the need for expertise guiding NGS implementation in laboratories and the lack of bioinformatic expertise, are main obstacles hindering the implementation of NGS into TB programs.
These series of webinars and tutorials aim at improving basic and
applied knowledge associated with next-generation sequencing (NGS)
technologies and their applications in the field of Tuberculosis (TB).
Published: 2024-06-03T09:32:41+00:00
Tags:
event, one-health, tuberculosis, NGS, Galaxy, training
Antimicrobial resistance (AMR) is a global phenomenon with no geographical or species boundaries, which poses an important threat to human, animal and environmental health. It is a complex and growing problem that compromises our ability to treat bacterial infections.
Pox viruses (Poxviridae) are a large family of viruses, and members of it have various vertebrate and arthropod species as their natural hosts. The most widely known species in the family are the now extinct variola virus from the genus orthopoxvirus as the cause of smallpox, and vaccinia virus, a related, likely horsepox virus, which served as the source for the smallpox vaccine that allowed eradication of that disease.
Of the four species of influenza viruses (Influenza A-D), Influenza A is the most virulent in human hosts and subtypes of it have been responsible for all historic flu pandemics.
In a disease outbreak situation, to understand the dynamics and the size of the outbreak, it is essential to detect transmission clusters to distinguish likely outbreak cases from unrelated background cases. Such detection is nowadays often based on actual sequencing data that enables quantitative conclusions about differences between pathogen isolates.
Sequence-based monitoring of global infectious disease crises, such as the COVID-19 pandemic, requires capacity to generate and analyze large volumes of sequencing data in near real time. These data have proven essential for surveilling the emergence and spread of new viral variants, and for understanding the evolutionary dynamics of the virus.
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. According to the WHO, in 2018 there were 10.0 million new cases of TB worldwide and 1.4 million deaths due to the disease, making TB the world’s most deadly infectious disease. The publication of the genome of M. tuberculosis H37Rv in 1998 gave researchers a powerful new tool for understanding this pathogen. This genome has been revised since then, with the latest version being available
This tutorial provides a companion to the work performed in March 2020 by InformaticsMatters, the Diamond Light Source, and the European Galaxy Team to perform virtual screening on candidate ligands for the SARS-CoV-2 main protease (MPro). This work is described in our dedicated site.
